Thermo Fisher Scientific CALM Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 290-460 of human PICALM (NP_0010086601) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CALM,uniProtId:Q13492-1,ncbiNodeId:9606,antigenRange:290-460,antigenLength:652,antigenImageFileName:PA5-87994_CALM_Q13492-1_Rabbit.svg,antigenImageFileNamePDP:PA5-87994_CALM_Q13492-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.53 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804572

Product Specific Information

Immunogen sequence: IKDSTAASRA TTLSNAVSSL ASTGLSLTKV DEREKQAALE EEQARLKALK EQRLKELAKK PHTSLTTAAS PVSTSAGGIM TAPAIDIFST PSSSNSTSKL PNDLLDLQQP TFHPSVHPMS TASQVASTWG GFTPSPVAQP HPSAGLNVDF ESVFGNKSTN VIVDSGGFDE L; Positive Samples: U-251MG, HepG2, MCF7, HeLa, Mouse lung; Cellular Location: Cytoplasmic vesicle, Golgi apparatus, Membrane, Nucleus, clathrin-coated pit, clathrin-coated vesicle

Target Information

PICALM, also known as the clathrin assembly lymphoid myeloid leukemia (CALM) protein, co-localizes with clathrin at clathrin-coated areas of the plasma membrane and in the Golgi area, and is thought to be an important component of the coated pit internalization machinery. Fusion proteins involving PICALM have been implicated in acute myeloid and T-cell acute lymphoblastic leukemia. PICALM is also expressed in neurons and is present at the synapse where it facilitates the endocytosis of the synaptic vesicle protein VAMP2. Recent studies have identified variants of PICALM associated with Alzheimer`s disease and have suggested this protein may play a role in the endocytosis and recycling of the amyloid protein precursor (APP).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.