Thermo Fisher Scientific CALM Polyclonal Antibody
CALM 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체. Western blot 및 ELISA에 적합하며, 인간과 생쥐 시료에 반응. PICALM 단백질 연구 및 알츠하이머 관련 연구에 활용 가능. 액상 형태로 -20°C에서 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 290–460 of human PICALM (NP_001008660.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.53 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804572 |
Product Specific Information
Immunogen sequence:
IKDSTAASRA TTLSNAVSSL ASTGLSLTKV DEREKQAALE EEQARLKALK EQRLKELAKK PHTSLTTAAS PVSTSAGGIM TAPAIDIFST PSSSNSTSKL PNDLLDLQQP TFHPSVHPMS TASQVASTWG GFTPSPVAQP HPSAGLNVDF ESVFGNKSTN VIVDSGGFDE LPositive Samples: U-251MG, HepG2, MCF7, HeLa, Mouse lung
Cellular Location: Cytoplasmic vesicle, Golgi apparatus, Membrane, Nucleus, clathrin-coated pit, clathrin-coated vesicle
Target Information
PICALM, also known as the clathrin assembly lymphoid myeloid leukemia (CALM) protein, co-localizes with clathrin at clathrin-coated areas of the plasma membrane and in the Golgi area. It is an important component of the coated pit internalization machinery. Fusion proteins involving PICALM have been implicated in acute myeloid and T-cell acute lymphoblastic leukemia. PICALM is also expressed in neurons and facilitates endocytosis of the synaptic vesicle protein VAMP2. Variants of PICALM are associated with Alzheimer’s disease and may play a role in endocytosis and recycling of the amyloid protein precursor (APP).
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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