Thermo Fisher Scientific MMP2 Monoclonal Antibody (CA-4001 (CA719E3C))

Applications and Tested Dilution

Product Specifications

Additional Formats

• Biotin
• Request custom conjugation

Product Specific Information

MA5-13590 targets MMP-2 (72 kDa Collagenase IV) in IA and WB applications and shows reactivity with Human, Mouse, and Rat samples.
The MA5-13590 immunogen is the N-terminal peptide APSPIIKFPGD-VAPKTDK of procollagenase IV.

Target Information

Matrix metalloproteinases (MMPs) are proteolytic enzymes capable of degrading connective tissue components.
They share a conserved amino acid sequence in the metal binding-active site region and are inhibited by tissue inhibitors of metalloproteinases (TIMPs).
MMPs and TIMPs play critical roles in regulating angiogenesis.

MMP2 is synthesized as a 631 amino acid proenzyme activated by cleavage of the first 80 amino acids. It contains propeptide, catalytic, and hemopexin domains.
MMPs collectively degrade components of the extracellular matrix, including collagens, fibronectin, laminin, and basement membrane glycoproteins.
Structurally, MMPs have a signal peptide, propeptide, and catalytic domain with a conserved zinc-binding site.

Functionally, MMP2 is involved in tissue remodeling.
Mutations in the MMP2 gene are associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome.
Two transcript variants encoding different isoforms of MMP2 have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.