Thermo Fisher Scientific MMP9 Monoclonal Antibody (GE-213)

Thermo Fisher Scientific MMP9 Monoclonal Antibody (GE-213)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

MA5-13595 targets MMP-9 (92kDa Collagenase IV) in IA, IHC (F), and IP applications and shows reactivity with Human samples.
The MA5-13595 immunogen is purified human MMP-9.

Target Information

MMP9 (matrix metallopeptidase 9, GELB, CLG4B) is a matrix metalloproteinase belonging to a family of zinc and calcium-dependent endopeptidases that degrade extracellular matrix proteins.
MMP9 is secreted as a 92kDa zymogen, and cleavage of pro-MMP9 produces the active 82kDa enzyme.
It has a gelatin-binding domain (three fibronectin type II units), a catalytic domain with a zinc-binding site, a proline-rich collagen-homologous domain, and a hemopexin-like domain.

MMP9 is expressed by monocytes, macrophages, neutrophils, keratinocytes, fibroblasts, osteoclasts, and endothelial cells. It plays roles in:

• Inflammatory responses
• Tissue remodeling and wound healing
• Tumor growth and metastasis

MMP9 contributes to skin carcinogenesis and degrades type IV and V collagens.
Studies suggest involvement in IL-8-induced mobilization of hematopoietic progenitor cells and tumor-associated tissue remodeling.
Elevated MMP9 levels correlate with idiopathic atrial fibrillation and aortic aneurysm progression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.