Thermo Fisher Scientific SOCS-5 Polyclonal Antibody
SOCS-5 단백질의 C-말단 합성 펩타이드를 면역원으로 제작된 Rabbit Polyclonal 항체. Western blot에 적합하며 인간 및 생쥐 시료에서 반응. 항원 친화 크로마토그래피로 정제, PBS 안정화 용액 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
- Western Blot (WB): 0.1–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the C-terminus of SOCS-5 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Endometrium tissue
- Cellular location: Cytoplasm
Target Information
Cytokine receptor signaling is negatively regulated by a family of Src homology 2 (SH2) domain-containing adaptor molecules termed SOCS (Suppressor of Cytokine Signaling). Eight members of the SOCS family have been recognized: SOCS-1, 2, 3, 4, 5, 6, 7, and CIS.
SOCS proteins consist of an N-terminal variable region, a central SH2 domain, and a C-terminal SOCS box motif. These proteins form part of a classical negative feedback loop regulating cytokine signal transduction via a STAT-induced transcriptional mechanism. SOCS gene transcription occurs rapidly in response to cytokines, and SOCS family members inhibit signaling through different mechanisms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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