Thermo Fisher Scientific HMBS Monoclonal Antibody (UMAB144), UltraMAB
HMBS 단백질을 인식하는 Thermo Fisher Scientific의 UMAB144 단클론 항체로, Western blot, IHC, ICC/IF에 사용 가능. 인간 유래 단백질에 반응하며, 동결건조 형태로 제공. 연구용으로 heme 합성 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunocytochemistry (ICC/IF) | 1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB144 |
| Immunogen | Full-length human recombinant HMBS protein produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
PBGD (porphobilinogen deaminase), also known as hydroxymethylbilane synthase (HMBS), is a cytoplasmic enzyme involved in the heme biosynthesis pathway.
Deficiency in PBGD causes acute intermittent porphyria (AIP), an inherited autosomal disorder characterized by acute neurological attacks, hypertension, tachycardia, peripheral neuropathy, abdominal pain, and elevated urinary aminolevulinic acid and porphobilinogen levels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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