Thermo Fisher Scientific Phospho-XPA (Ser196) Polyclonal Antibody
XPA 단백질의 Ser196 인산화 형태를 특이적으로 인식하는 폴리클로날 항체. Western blot에 적합하며, 인간, 마우스, 비인간 영장류 시료에 반응. 1 mg/mL 농도의 액상 형태로 제공되며, PBS/glycerol 완충액에 보관. 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human XPA (Accession P23025), corresponding to amino acid residues around phosphorylated Ser196. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817455 |
Product Specific Information
This antibody detects endogenous levels of XPA only when phosphorylated at Ser196.
Target Information
The XPA (xeroderma pigmentosum group A) protein specifically recognizes UV- or chemically damaged DNA lesions and triggers the nucleotide excision repair process. XPA binds to replication protein A (RPA) or the excision repair cross-complementing 1 protein (ERCC1). In the absence of nucleotide excision repair, persisting (unrepaired) DNA lesions may lead to the accumulation of gene mutations and ultimately to cancer. Xeroderma pigmentosum patients have a more than 2000-fold increased risk of developing skin cancer in sun-exposed areas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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