Thermo Fisher Scientific Phospho-IP3 Receptor 1 (Tyr353) Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:3,000

-

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human ITPR1(Accession Q14643), corresponding to amino acid residues around phosphorylated Tyr353. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:IP3 Receptor 1,uniProtId:Q14643-1,ncbiNodeId:9606,antigenRange:353,antigenLength:2758,antigenImageFileName:PA5-106062_IP3_Receptor_1_Q14643-1_Rabbit.svg,antigenImageFileNamePDP:PA5-106062_IP3_Receptor_1_Q14643-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2817461

Product Specific Information

Antibody detects endogenous levels of IP3 Receptor only when phosphorylated at Tyr353.

Target Information

Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.