Thermo Fisher Scientific Guanylyl Cyclase beta 1 Polyclonal Antibody, Biotin

Applications and Tested Dilutions

Product Specifications

Target Information

Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase: a soluble form (GCS or sGC), which acts as a receptor for nitric oxide, and a membrane-bound receptor form (GC), which functions as a peptide hormone receptor.
The GC-C protein comprises an extracellular domain, a single transmembrane domain, and a cytoplasmic region containing a kinase-like and a catalytic domain. It exists as two glycosylated forms: a 130 kDa precursor in the endoplasmic reticulum and a 145 kDa form on the plasma membrane.
Ligand binding to the extracellular domain of GC-C promotes cGMP accumulation. GC-C acts as the receptor for heat-stable enterotoxins from certain pathogenic E. coli strains that cause secretory diarrhea and also binds guanylin and uroguanylin peptides, which regulate renal function in response to salt intake.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.