Thermo Fisher Scientific Guanylyl Cyclase beta 1 Polyclonal Antibody, Biotin
Guanylyl Cyclase beta 1 단백질을 인식하는 Biotin 결합 토끼 폴리클로날 항체로, WB, IHC, ICC, ELISA 등 다양한 응용에 적합합니다. Bovine, Human, Mouse, Pig, Rat에 반응하며, 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- SGCB-BIOTIN
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| Immunocytochemistry (ICC/IF) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
| Immunomicroscopy (IM) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Human, Mouse, Pig, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 175–225 on rat guanylate cyclase soluble subunit beta-1 protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase: a soluble form (GCS or sGC), which acts as a receptor for nitric oxide, and a membrane-bound receptor form (GC), which functions as a peptide hormone receptor.
The GC-C protein comprises an extracellular domain, a single transmembrane domain, and a cytoplasmic region containing a kinase-like and a catalytic domain. It exists as two glycosylated forms: a 130 kDa precursor in the endoplasmic reticulum and a 145 kDa form on the plasma membrane.
Ligand binding to the extracellular domain of GC-C promotes cGMP accumulation. GC-C acts as the receptor for heat-stable enterotoxins from certain pathogenic E. coli strains that cause secretory diarrhea and also binds guanylin and uroguanylin peptides, which regulate renal function in response to salt intake.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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