Thermo Fisher Scientific Soluble Guanylyl Cyclase alpha 1 Polyclonal Antibody, Biotin
Biotin으로 표지된 다클론 항체로, 인간, 마우스, 랫트의 sGC α1 단백질 검출에 적합합니다. Western blot, ELISA, IP에 사용 가능하며, 합성 펩타이드 면역원으로 제작되었습니다. -20°C에서 보관하며 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide taken within amino acid region 654–704 on rat Guanylyl cyclase alpha 1 subunit protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase: a soluble form (GCS or sGC), which acts as a receptor for nitric oxide, and a membrane-bound receptor form (GC), which serves as a peptide hormone receptor.
The GC-C protein contains an extracellular domain, a single transmembrane domain, and a cytoplasmic region consisting of a kinase-like and a catalytic domain. It exists as two glycosylated forms: a 130 kDa precursor in the endoplasmic reticulum and a 145 kDa mature form on the plasma membrane.
Ligand binding to GC-C promotes cGMP accumulation. GC-C functions as a receptor for heat-stable enterotoxins secreted by pathogenic E. coli, causing secretory diarrhea, and also binds guanylin and uroguanylin peptides that regulate renal function in response to salt intake.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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