Thermo Fisher Scientific Phospho-FMRP (Ser499) Polyclonal Antibody
Phospho-FMRP (Ser499) 항체로 Western blot 및 IHC에 적합. Rabbit Polyclonal 형식으로 다양한 종에 반응. 고순도 Affinity chromatography 정제, 안정적 액상 형태. FMR1 단백질의 인산화 상태 연구에 유용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
- Publications: View 1 publication
Immunohistochemistry (IHC)
- Tested Dilution: 1:250–1:1,000
- Publications: None listed
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Chicken, Human, Mouse, Rat |
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser499 of rat FMR1 conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | ~0.4 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.1 mg/mL BSA, 0.15M NaCl, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2552699 |
Product Specific Information
This antibody is predicted to react with bovine, canine, chicken, human, mouse, non-human primate, sheep, Xenopus, and zebrafish based on 100% sequence homology.
This antibody contains enough material to conduct 10 mini-Western blots.
Target Information
FMR1 binds RNA and is associated with polysomes. The protein may be involved in mRNA trafficking from the nucleus to the cytoplasm.
A trinucleotide repeat in the 5′ UTR is normally found at 6–53 copies, but expansion to 55–230 repeats causes fragile X syndrome.
Expansion of the repeat may also lead to one form of premature ovarian failure.
Multiple alternatively spliced transcript variants encoding different protein isoforms located in distinct cellular compartments have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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