Thermo Fisher Scientific CD122 Monoclonal Antibody (TM-b1 (TM-beta1)), eBioscience
Mouse CD122(IL-2Rβ) 인식하는 Rat monoclonal antibody로, Flow Cytometry, Immunoprecipitation, Neutralization 등에 사용 가능. 비결합형(Unconjugated) 형식이며, 고순도(>90%)로 제조되어 연구용에 적합. 4°C 보관, PBS buffer 포함.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Flow Cytometry (Flow) | 0.5 µg/test | 10 publications |
| Immunoprecipitation (IP) | Assay-Dependent | - |
| Neutralization (Neu) | Assay-Dependent | 1 publication |
| Functional Assay (Functional) | Assay-Dependent | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TM-b1 (TM-beta1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_467447 |
Additional Available Formats
- APC
- Biotin
- eFluor 450
- FITC
- Functional Grade
- PE
- PE-Cyanine7
- PerCP-eFluor 710
- Super Bright 436
- Request custom conjugation available
Product Specific Information
The TM-b1 monoclonal antibody reacts with mouse CD122, the 90–110 kDa interleukin-2 receptor beta chain (IL-2Rβ). CD122 is expressed by NK cells and some T cells, and is upregulated upon activation. It associates with CD25 and CD132 (common gamma chain) to form the high-affinity IL-2 receptor. Binding of IL-2 to its receptor is inhibited by TM-b1 antibody.
Applications Reported: Flow cytometric analysis, cytokine neutralization, and immunoprecipitation.
Applications Tested: Flow cytometric analysis of mouse splenocytes at ≤0.5 µg/test (in 100 µL final volume). Optimal antibody titration recommended.
Purity: >90% (SDS-PAGE)
Aggregation: <10% (HPLC)
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
CD122 (Interleukin-2 receptor beta chain) is involved in T cell-mediated immune responses and is primarily expressed in the hematopoietic system. It exists in three affinity forms:
- Low affinity: alpha subunit monomer (no signal transduction)
- Intermediate affinity: alpha/beta heterodimer
- High affinity: alpha/beta/gamma heterotrimer
The intermediate and high affinity forms mediate receptor endocytosis and mitogenic signaling. The CD122 gene encodes the beta subunit, a type I membrane protein. Dysfunction in CD122 is associated with oligoarticular juvenile idiopathic arthritis and rheumatoid factor-negative juvenile idiopathic arthritis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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