Thermo Fisher Scientific Synphilin-1 Polyclonal Antibody
Synphilin-1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC에 적합합니다. 인간 Synphilin-1 내부 영역 펩타이드를 면역원으로 사용하였으며, 파킨슨병 연구에 유용합니다. 동결건조 형태로 제공되며, 4°C 또는 -20°C에서 보관 가능합니다.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Synphilin-1 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | - |
| Immunohistochemistry (IHC) | 10–50 µg/mL | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the internal region of human Synphilin-1 (Synphilin 1, alpha synuclein interacting protein) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C for short term. For long-term storage, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: Synphilin-1.
Target Information
Parkinson’s disease is the second most common neurodegenerative disorder after Alzheimer’s disease, affecting approximately 1% of people over 65 and 3% over 75.
Synphilin-1 (Synuclein alpha interacting protein, SNCAIP) interacts with alpha-synuclein in neurons and contains multiple protein-protein interaction domains.
Mutations in SNCAIP have been linked to Parkinson’s disease. The amino acid sequence of synphilin-1 shows strong homology with its human counterpart, particularly in ankyrin-like motifs and coiled-coil domains.
Expression patterns of mouse and human synphilin-1 are similar. Synphilin-1 plays a critical role in aggregate formation and cytotoxicity in Parkinson’s disease, potentially involving Dorfin-mediated ubiquitylation. It is also implicated in synaptic function, protein degradation, and neurodegenerative mechanisms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.