Thermo Fisher Scientific Synphilin 1 Polyclonal Antibody
Synphilin 1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체입니다. Western Blot 및 Immunohistochemistry에 사용 가능하며, 인간 시료에 반응합니다. Parkinson 병 관련 연구용으로 적합하며, 동결 건조 형태로 제공됩니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | View publications |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | View publications |
| Miscellaneous PubMed (Misc) | – | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the internal region of human Synphilin 1 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: Synphilin-1.
Target Information
Parkinson’s disease is the second most common neurodegenerative disorder after Alzheimer’s, affecting about 1% of people over 65 and 3% over 75.
Synphilin-1 (Synuclein alpha interacting protein, SNCAIP) interacts with alpha-synuclein in neurons and mutations in SNCAIP are linked to Parkinson’s disease.
Synphilin-1 contains ankyrin-like motifs and coiled-coil domains, showing extensive homology with its human counterpart.
Expression patterns in mouse tissues are similar to human. Synphilin-1 plays a key role in aggregate formation and cytotoxicity in Parkinson’s disease. Dorfin may be involved through ubiquitylation of synphilin-1.
It contributes to synaptic function, protein degradation, and neurodegeneration mechanisms in Parkinson’s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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