Thermo Fisher Scientific LXR alpha Monoclonal Antibody (PPZ0412)
인간, 생쥐, 랫트의 LXR alpha를 특이적으로 인식하는 단클론 항체로, 다양한 분석법(WB, IHC, ELISA 등)에 적용 가능. 비결합형 액상 형태이며 1 mg/mL 농도로 제공. 장기 보관 시 -20°C에서 안정적으로 유지됨.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3–20 µg/mL |
| ELISA | 0.2 µg/mL |
| Immunoprecipitation (IP) | Assay-dependent |
| ChIP assay (ChIP) | Assay-dependent |
| Gel Shift (GS) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Rat, Human, Mouse |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PPZ0412 |
| Immunogen | Produced in BALB/c mouse ascites after inoculation with hybridoma of mouse myeloma cells (NS-1) and spleen cells derived from a BALB/c mouse immunized with E.coli-expressed recombinant human LXR-alpha (164–447 aa). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | Physiological saline |
| Contains | 0.1% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 1 month. For long-term storage, store at -20°C. |
| Shipping Conditions | Wet ice |
| RRID | AB_2532200 |
Product Specific Information
This antibody specifically recognizes human LXR alpha and cross-reacts with mouse and rat LXR alpha. It does not recognize human LXR beta.
Target Information
NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor exhibiting ligand-dependent transcriptional activation. Its interaction with retinoic acid receptor (RXR) converts RXR from a silent DNA-binding partner to an active ligand-binding subunit, mediating retinoid responses through LXRES—DR4-type response elements with two hexanucleotide half-sites spaced by four nucleotides.
NR1H3 is crucial for cholesterol homeostasis, regulating uptake via MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8, and functionally interacts with RORA to regulate genes involved in liver metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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