Thermo Fisher Scientific GFI1 Monoclonal Antibody (OTI6C10), TrueMAB
인간 GFI1 단백질을 인식하는 마우스 단일클론 항체로, Western blot에 적합합니다. 정제된 항체로 보존제가 없으며, 동결건조 형태로 제공됩니다. 혈액세포 발달 및 림프종 관련 연구에 활용 가능합니다.
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6C10 |
| Immunogen | Full length human recombinant protein of human GFI1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
GFI1 is a nuclear zinc finger transcriptional repressor involved in hematopoiesis and inner ear development, and is implicated in lymphomagenesis.
GFI1 expression is regulated by the ubiquitin-proteasome system, and the Triad1 ubiquitin ligase interacts with its DNA-binding domain.
GFI1 represses transcription by binding directly to consensus DNA sequences in target gene promoters.
Deficiency of GFI1 causes neutropenia and accumulation of granulomonocytic precursor cells, resembling myelodysplastic syndrome in mice.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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