
Thermo Fisher Scientific CD18 Monoclonal Antibody (M18/2), FITC
CD18 항원을 인식하는 FITC 결합 단클론 항체로, 마우스 시료에 적합합니다. 세포 표면의 β2 인테그린을 검출하며, 유세포분석(Flow Cytometry)에 사용됩니다. 액상 형태로 제공되며, 4°C 암소 보관이 필요합니다.
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Applications
- Flow Cytometry (Flow): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | M18/2 |
| Immunogen | Murine cytotoxic T cell glycoproteins |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Size-exclusion chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153747 |
Additional Formats
Product Specific Information
This antibody recognizes an extracellular epitope of the CD18 antigen (integrin beta2 subunit; beta2 integrin), a 95 kDa type I transmembrane protein expressed on all leukocytes.
This antibody will not cross-react with canine.
Target Information
CD18 integrin beta 2 subunit is a 90 kDa type I transmembrane protein expressed on all leukocytes.
CD18 can combine with integrin molecules CD11a–c to form heterodimers at the cell surface, participating in cell adhesion and signaling.
These heterodimers include:
- αLβ2 (CD11a/CD18, LFA-1)
- αMβ2 (CD11b/CD18, Mac-1, CR3)
- αXβ2 (CD11c/CD18)
- αDβ2 (CD11d/CD18)
These integrins are essential for proper leukocyte migration and intercellular contact.
Deficiency in CD18 leads to leukocyte adhesion deficiency type I (LAD1).
CD18 is also a target of Mannheimia haemolytica leukotoxin, mediating leukotoxin-induced cytolysis.
Two transcript variants encoding the CD18 protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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