Thermo Fisher Scientific CD18 Monoclonal Antibody (M18/2), FITC

Applications

• Flow Cytometry (Flow): 1–2 µg/mL

Product Specifications

Additional Formats

• Unconjugated
• Request custom conjugation

Product Specific Information

This antibody recognizes an extracellular epitope of the CD18 antigen (integrin beta2 subunit; beta2 integrin), a 95 kDa type I transmembrane protein expressed on all leukocytes.
This antibody will not cross-react with canine.

Target Information

CD18 integrin beta 2 subunit is a 90 kDa type I transmembrane protein expressed on all leukocytes.
CD18 can combine with integrin molecules CD11a–c to form heterodimers at the cell surface, participating in cell adhesion and signaling.
These heterodimers include:

• αLβ2 (CD11a/CD18, LFA-1)
• αMβ2 (CD11b/CD18, Mac-1, CR3)
• αXβ2 (CD11c/CD18)
• αDβ2 (CD11d/CD18)

These integrins are essential for proper leukocyte migration and intercellular contact.
Deficiency in CD18 leads to leukocyte adhesion deficiency type I (LAD1).
CD18 is also a target of Mannheimia haemolytica leukotoxin, mediating leukotoxin-induced cytolysis.
Two transcript variants encoding the CD18 protein have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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