Thermo Fisher Scientific SATB2 (Colorectal Carcinoma Marker) Monoclonal Antibody (rSATB2/6929)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 2 µg/mL

Immunohistochemistry (PFA fixed) (IHC (PFA))

• Tested Dilution: 1–2 µg/mL

Product Specifications

Target Information

DNA-binding protein SATB2 binds to DNA at nuclear matrix- or scaffold-associated regions and recognizes the sugar-phosphate structure of double-stranded DNA.
It functions as a transcription factor controlling nuclear gene expression by binding to matrix attachment regions (MARs) and inducing local chromatin-loop remodeling.
SATB2 also serves as a docking site for chromatin remodeling enzymes, recruiting corepressors (HDACs) or coactivators (HATs) to promoters and enhancers.
It is essential for initiating upper-layer neuron (UL1) genetic programs and repressing deep-layer (DL) and UL2-specific genes, likely through modulation of BCL11B expression.
SATB2 acts as a repressor of Ctip2 and a key regulator of corticocortical connections in the developing cerebral cortex.
Mutations in the SATB2 gene are associated with isolated cleft palate (CPI).

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.