Thermo Fisher Scientific SHIP1 Monoclonal Antibody (T.7.7)
SHIP1 단백질을 인식하는 Rabbit monoclonal antibody로 Western blot, ICC/IF, Flow cytometry, IP에 사용 가능. 인간 샘플에 반응하며, 고순도 친화 크로마토그래피 정제. 액상 형태로 안정적이며 -20°C에서 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:400 |
| Flow Cytometry (Flow) | 1:200 |
| Immunoprecipitation (IP) | 1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | T.7.7 |
| Immunogen | Synthetic peptide corresponding to residues surrounding Trp942 of human SHIP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 44 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10977220 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
This gene belongs to the inositol polyphosphate-5-phosphatase (INPP5) family. It encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression is restricted to hematopoietic cells, where its translocation to the plasma membrane is mediated by tyrosine phosphorylation. At the membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, affecting multiple signaling pathways. It functions as a negative regulator of myeloid cell proliferation and survival. Alternate splice variants encoding different isoforms have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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