Thermo Fisher Scientific ErbB3 Monoclonal Antibody (2B11D11)
ERBB3 단백질을 인식하는 Mouse Monoclonal Antibody로, Human 시료에서 Western blot 및 ELISA에 적합합니다. 정제된 재조합 단백질(aa1175-1275)을 면역원으로 사용하였으며, 비결합형 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2B11D11 |
| Immunogen | Purified recombinant fragment of ERBB3 (aa1175–1275) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Ascites |
| Contains | 0.03% sodium azide |
| Storage Conditions | Store at 4 °C for short term; for long term, store at −20 °C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10986108 |
Product Specific Information
MA5-15438 targets ERBB3 in indirect ELISA and WB applications and shows reactivity with human samples.
The immunogen is a purified recombinant fragment of ERBB3 (aa1175–1275) expressed in E. coli.
Target Information
ErbB3 (c‑erbB‑3/HER‑3) is a member of the type I family of growth factor receptors and binds to ligands in the heregulin family.
It is overexpressed in various tumors including those of the prostate, bladder, breast, stomach, pancreas, and colon.
Heregulin and EGF stimulate tyrosine phosphorylation of c‑erbB‑3 to varying degrees.
The ErbB3 gene is located on chromosome 12q13 and encodes a 160/180 kDa glycoprotein.
ErbB3 forms heterodimers with other EGF receptor family members possessing kinase activity, leading to activation of pathways involved in cell proliferation or differentiation.
Alternative splicing produces several isoforms, including a secreted form that modulates the activity of the membrane‑bound receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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