Thermo Fisher Scientific ErbB3 Monoclonal Antibody (3F10F6)
Human ErbB3 단백질을 인식하는 Mouse Monoclonal Antibody로, WB, IHC(P), ELISA에 사용 가능. Recombinant fragment (aa1175-1275)을 면역원으로 제작. Unconjugated 형태이며, 장기 보관 시 -20°C에서 보관 권장.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| ELISA | 1:10,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3F10F6 |
| Immunogen | Purified recombinant fragment of ERBB3 (aa1175–1275) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Ascites |
| Contains | 0.03% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_10983427 |
Product Specific Information
MA5-15437 targets ERBB3 in indirect ELISA, IHC, and WB applications and shows reactivity with human samples.
The immunogen is a purified recombinant fragment of ERBB3 (aa1175–1275) expressed in E. coli.
Target Information
ErbB3 (c-erbB-3/HER-3) is a member of the type I family of growth factor receptors and binds ligands in the heregulin family.
ErbB3 is over-expressed in various tumors, including prostate, bladder, breast, stomach, pancreas, and colon.
Heregulin and EGF stimulate tyrosine phosphorylation of c-erbB-3 to different extents.
The ErbB3 gene is located on the long arm of human chromosome 12 (12q13) and transcribed into a 6.2 kb mRNA, translating into a 160/180 kDa glycoprotein.
It encodes a transmembrane receptor tyrosine kinase that forms heterodimers with other EGF receptor family members, activating pathways for cell proliferation or differentiation.
Alternate splice variants encoding different isoforms of ErbB3 have been characterized, including a secreted form that modulates the activity of the membrane-bound receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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