Thermo Fisher Scientific Phospho-Chemokine Receptor 5 (Ser336, Ser337) Polyclonal Antibody
Human CCR5 단백질의 Ser336/Ser337 인산화 부위를 인식하는 Rabbit Polyclonal Antibody. Western blot에 1:1,000 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제된 액상형 제품으로, 단기 4°C, 장기 -20°C 보관. HIV 관련 연구용으로 적합.
- 카탈로그번호
- 7TM0062A
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB): Tested dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human CCR5 around the phosphorylation site of Ser336/Ser337 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco's PBS, pH 7.4 |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
Human immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to CD4, to infect target cells.
G protein-coupled receptors such as CCR5, CXCR4, CCR3, CCR2b, and CCR8 serve as chemokine receptor family members acting as HIV coreceptors.
CCR5 (CC-CKR-5) is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains, facilitating fusion and entry into human white blood cells.
CCR5 is required for infection by HIV-1, HIV-2, and SIV. Beta-chemokines RANTES, MIP-alpha, and MIP-beta are ligands for CCR5 and prevent infection by M-tropic HIV-1.
CCR5 associates with the surface CD4-gp120 complex of HIV, leading to membrane fusion and viral entry into target cells.
The amino-terminal domain and extracellular loops of CCR5 serve as HIV binding sites. CCR5 mRNA is expressed in lymphoid organs and monocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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