Thermo Fisher Scientific Phospho-ESR2 (Ser105) Polyclonal Antibody
인간, 생쥐, 랫트 시료에서 Ser105 위치의 인산화된 Estrogen Receptor beta를 특이적으로 검출하는 폴리클로날 항체. Western Blot 및 Immunocytochemistry에 적합. 고순도 정제 및 안정적 PBS/glycerol 저장용액 제공.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ESR2 (Accession Q92731), corresponding to amino acid residues around phosphorylated Ser105 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816493 |
Product Specific Information
This antibody detects endogenous levels of Estrogen Receptor-beta only when phosphorylated at Serine 105.
Target Information
Estrogen Receptor beta (ER beta, NR3A2) is a nuclear receptor protein (~55 kDa) with multiple isoforms (36–59 kDa). It functions as a ligand-activated transcription factor regulating gene expression through estrogen response elements (EREs). ER beta and ER alpha are encoded by separate genes (ESR2 and ESR1). ER beta is expressed widely and may act as a tumor suppressor, with implications in prostate cancer, autism spectrum disorder, thyroid carcinoma, and cardiovascular disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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