Thermo Fisher Scientific PI4KII alpha Polyclonal Antibody
PI4KII alpha 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체. Western blot, IHC, ELISA, IP 등 다양한 응용 가능. 인간 반응성, 고순도 친화 크로마토그래피 정제. 장기 보관 시 -20°C에서 안정적 유지.
- 카탈로그번호
- 600-401-J93
- 판매단위
- pk
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Thermo Fisher Scientific PI4KII alpha Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (IHC) | Assay-dependent |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Anti-PI4KII alpha affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide at the N-terminal of human P4K2A protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.31 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 50% glycerol, 0.15M NaCl |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.
A BLAST analysis suggests cross-reactivity with human, mouse, and rat based on 100% sequence homology. Cross-reactivity with PI4KII alpha from other sources has not been determined.
Target Information
PI4K2A (PI4K2 alpha) is a lipid kinase involved in the formation of phosphatidylinositolpolyphosphates (PtdInsPs), which play central roles in cell growth, actin cytoskeleton organization, and vesicular trafficking.
PI4K2A phosphorylates PtdIns at the D-4 position, a critical step in PtdInsPs biosynthesis. It acts as a regulator of tumor growth through angiogenesis and HIF-1alpha regulation.
PI4K2A generates PtdIns4P-rich domains within the Golgi, regulating clathrin adaptor AP-1 targeting and is required for Wnt-mediated LRP6 phosphorylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: 600-401-J93_PI4K2A_Q9BTU6-1_Rabbit.svg, 600-401-J93_PI4K2A_Q9BTU6-1_Rabbit_PDP.jpeg)
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