Thermo Fisher Scientific Ly-6G Monoclonal Antibody (1A8-Ly6g), Alexa Fluor 700, eBioscience
마우스 Ly-6G(Gr-1) 항원을 인식하는 단클론 항체로, Alexa Fluor 700으로 표지되어 있습니다. 주로 유세포분석(Flow Cytometry)에 사용되며, 중성구(neutrophil) 특이적 결합 특성을 가집니다. 0.2 mg/mL 농도의 액상 형태로 제공되며, 4°C 암소 보관이 권장됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 4 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | - | View 2 publications |
| Flow Cytometry (Flow) | 0.5 µg/test | View 22 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), Alexa Fluor™ 700, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1A8-Ly6g |
| Conjugate | Alexa Fluor™ 700 |
| Excitation / Emission Max | 696 / 719 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2802355 |
Available Formats
- APC
- APC-eFluor 780
- Biotin
- Brilliant UV 395
- Brilliant UV 563
- Brilliant UV 661
- Brilliant UV 737
- Brilliant Violet 421
- Brilliant Violet 480
- Brilliant Violet 650
- Brilliant Violet 786
- eFluor 450
- FITC
- Functional Grade
- PE
- PE-Cyanine5
- PE-Cyanine7
- PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Super Bright 702
- Request custom conjugation
Product Specific Information
The monoclonal antibody 1A8-Ly6g reacts with mouse Ly-6G (Gr-1), a 25 kDa GPI-anchored protein expressed exclusively by neutrophils. Ly-6G plays a role in neutrophil infiltration, recruitment, and migration, and associates with β2 integrins CD11a and CD11b, modulating their expression and function.
Unlike the RB6-8C5 antibody, 1A8-Ly6g binds only to Ly-6G on neutrophils and is used for neutrophil depletion and functional inhibition studies.
Applications Reported: Flow cytometric analysis
Applications Tested: Tested on mouse bone marrow cells at ≤0.5 µg/test. Optimize concentration empirically depending on cell number (10⁵–10⁸ cells/test).
Fluorochrome Information:
- Excitation: 633–647 nm
- Emission: 723 nm
- Laser: Red
Use a 685 LP mirror and 710/20 band-pass filter for detection.
Target Information
Ly6G (Lymphocyte antigen 6 complex locus G6D) is part of the myeloid differentiation antigen Gr-1 complex, along with Ly6C.
It is a 21–25 kDa protein expressed by myeloid-derived cells in bone marrow and serves as a marker for neutrophils, monocytes, and granulocytes. Expression of Gr-1 correlates with granulocyte differentiation and maturation.
Ly6G has been implicated in anti-tumor immune responses and may modulate local immune activity via neutrophil signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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