Thermo Fisher Scientific CEACAM8 Monoclonal Antibody (80H3)
CEACAM8 단백질을 표적으로 하는 Thermo Fisher Scientific의 Mouse IgG1 단클론 항체. Western blot, IHC(F), Flow cytometry 등 다양한 연구용 응용에 적합. 인간 시료 반응성, Protein A 정제, 액상 형태로 제공.
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Thermo Fisher Scientific CEACAM8 Monoclonal Antibody (80H3)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC(F)) | 1:25–1:100 |
| Flow Cytometry (Flow) | 1:50–1:100 |
| Functional Assay | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 80H3 |
| Immunogen | Human leukocytes from individuals with CML (Target: CD66b / CEACAM8, UniProt ID: P31997-1, Antigen range: 1–349) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 0.5% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_779729 |
Product Specific Information
- Recommended positive controls: Bone marrow
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
Target Information
This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, belonging to the immunoglobulin superfamily. Two subgroups of the CEA family—the CEA cell adhesion molecules and the pregnancy-specific glycoproteins—are located within a 1.2 Mb cluster on chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found within this cluster.
The encoded protein was first identified in bile ducts of the liver as biliary glycoprotein and later found to be a cell-cell adhesion molecule expressed on leukocytes, epithelia, and endothelia. It mediates adhesion via homophilic and heterophilic interactions with other subgroup proteins. Reported cellular roles include tissue differentiation and structural organization, angiogenesis, apoptosis, tumor suppression, metastasis, and modulation of immune responses. Multiple transcript variants exist, though full-length sequences are not completely defined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without authorization.
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