Thermo Fisher Scientific ITGA4 Monoclonal Antibody (PS/2)
Thermo Fisher Scientific의 ITGA4 Monoclonal Antibody (PS/2)는 인간 및 마우스 CD49d(Integrin α4)를 인식하는 Rat IgG2b 단클론 항체입니다. IHC, Flow Cytometry, IP, 기능적 분석 등 다양한 응용에 적합하며, 저엔도톡신·보존제 무첨가 포뮬레이션으로 연구용에 최적화되었습니다.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | |
| Flow Cytometry (Flow) | 1:50–1:100 | |
| Immunoprecipitation (IP) | Assay-dependent | |
| Functional Assay (Functional) | Assay-dependent | |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rat / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PS/2 |
| Immunogen | P815 DBA/2 murine mastocytoma cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2265172 |
Product Specific Information
- Low-endotoxin, preservative-free formulation.
- For FACS analysis, use 10 µL of the suggested working dilution to label 1×10^6 cells in 100 µL.
- Rat anti-Mouse CD49d monoclonal antibody, clone PS/2 recognizes murine alpha 4 integrin (CD49d), a ~150 kDa single-pass type I membrane glycoprotein.
- Forms heterodimers with beta 1 (CD29) or beta 7 integrin to create CD49d/CD29 (VLA-4) and alpha4/beta7 (LPAM-1).
(Reference: Holzmann et al., 1989)
Target Information
Integrin alpha 4 (CD49d, ITGA4) is a member of the integrin alpha chain family.
Integrins are heterodimeric membrane proteins composed of alpha and beta chains.
Alpha4 associates with beta1 or beta7 chains, forming integrin α4β1 and α4β7 complexes.
Ligands include MadCAM, VCAM, and fibronectin. MadCAM is the principal ligand for α4β7.
HIV-1 envelope can mimic MadCAM by binding and signaling through α4β7, the gut mucosal homing receptor for peripheral T cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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