Thermo Fisher Scientific Phospho-TAK1 (Ser192) Polyclonal Antibody
TAK1 단백질의 Ser192 인산화 부위를 인식하는 Rabbit Polyclonal Antibody. WB, IHC, ICC/IF, Flow, ELISA 등 다양한 응용 가능. Human, Mouse, Rat 반응성. 고순도 Protein A 정제, -20°C 보관.
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Thermo Fisher Scientific Phospho-TAK1 (Ser192) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human TAK1 around the phosphorylation site of Ser192 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TAK1 (also known as MAP3K7) is a serine/threonine kinase involved in multiple signaling pathways. Initially identified as a TGF-β activated kinase, TAK1 interacts with TGF-β receptors and TRAF6 to modulate activation of JNK and p38. It also participates in Wnt, BMP, and activin signaling, and responds to thyroid hormone, osmotic stress, and endothelin. TAK1 regulates wound healing via activation of von Hippel-Lindau tumor suppressor and represses PDGF-B and integrins. Furthermore, TAK1 is essential for IKK activation through IL-1, IL-6, IL-18, TNF, CD40, TLR, and RIG-I pathways. Activation involves TAB2/3 binding, polyubiquitination, and TAK1 autophosphorylation at Thr178, Thr184, Thr187, and Ser192, leading to phosphorylation of IKK-β. TAK1 also represses human telomerase reverse transcriptase, influencing cell lifespan regulation.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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