Thermo Fisher Scientific PLCG2 Polyclonal Antibody
PLCG2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. 인간 및 마우스 반응성. 고순도 항원 친화 크로마토그래피 정제. 1 mg/mL 농도, 4°C 또는 -20°C 저장.
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Thermo Fisher Scientific PLCG2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 720–770 of Human PLCγ2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803024 |
Product Specific Information
- Purity > 95% by SDS-PAGE.
Target Information
Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in receptor-mediated signal transduction by generating two second messengers, inositol 1,4,5-triphosphate and diacylglycerol, from phosphatidylinositol 4,5-bisphosphate.
There are multiple mammalian PLC isozymes, including PLCβ1–β4, PLCγ1–γ2, PLCδ1–δ2, and PLCε.
PLCδ1 acts as a calcium signal amplifier and is activated by an atypical GTP-binding protein. It functions as an effector for GTP-binding protein transglutaminase II-mediated oxytocin receptor and α1B-adrenoreceptor signaling.
Mouse PLCδ1 is highly expressed in brain, heart, lung, and testis. Abnormal accumulation of PLCδ is observed in Alzheimer’s disease brains, suggesting a potential role in AD pathology.
PLCδ2 expression is associated with gastric malignant transformation and may serve as a potential biomarker.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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