Thermo Fisher Scientific Caspase 5 Polyclonal Antibody
Caspase-5 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunocytochemistry에 적합합니다. Human과 Mouse 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며, 2–8°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 14 amino acid peptide from the center of human Caspase-5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage store at -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152011 |
Product Specific Information
- A suggested positive control is Ramos cell lysate.
- PA5-20111 can be used with blocking peptide PEP-0229.
Target Information
Caspases are a family of cysteine proteases divided into apoptotic and inflammatory subfamilies. Unlike apoptotic caspases, the inflammatory caspases (such as caspase-1, -4, -5, and -12) are primarily associated with immune responses to microbial pathogens rather than cell death. Activation of these caspases leads to cleavage and activation of proinflammatory cytokines such as IL-1β and IL-18.
Caspase-5 can interact with caspase-1, and both are components of the NALP1 inflammasome, a complex that triggers cleavage of pro-IL-1β. Expression of caspase-5 can be regulated by lipopolysaccharide (LPS) and IFN-γ.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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