Thermo Fisher Scientific DMAP1 Polyclonal Antibody

Thermo Fisher Scientific DMAP1 Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 1:1,000–1:5,000

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

DNA methyltransferase 1-associated protein 1 (DMAP1) is involved in transcriptional repression or activation.
This protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting with the N-terminus of DNA methyltransferase 1.
During late S phase, histone deacetylase 2 joins this complex, enabling histone deacetylation in transcriptionally inactive heterochromatin.
DMAP1 also potentiates DAXX-mediated repression of glucocorticoid receptor-dependent transcription.
It is part of the nucleosome acetyltransferase of H4 complex and interacts with transcriptional corepressor TSG101 and pro-apoptotic DAXX.
DMAP1 is conserved across organisms from yeast to humans, and the human DMAP1 gene is localized on chromosome 1p34.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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