Thermo Fisher Scientific Kaiso Polyclonal Antibody
Rabbit polyclonal antibody against human Kaiso transcriptional regulator. Validated for WB and IP applications. Unconjugated liquid form with 1 mg/mL concentration. Recommended storage at 4°C and 1-year shelf life. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 375–425 of human Transcriptional regulator Kaiso |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, binding to both methylated CGCG and non-methylated KAISO-binding site (TCCTGCNA).
The protein includes an N-terminal POZ/BTB domain and three C-terminal zinc finger motifs.
It recruits the N-CoR repressor complex to promote histone deacetylation and formation of repressive chromatin structures in target gene promoters.
Kaiso may contribute to repression of Wnt signaling pathway target genes and can activate transcription of certain genes via catenin delta-2 (CTNND2) recruitment.
Interaction with catenin delta-1 (CTNND1) inhibits DNA binding.
It also interacts directly with Importin-alpha 2 (karyopherin alpha2), mediating nuclear import.
Alternatively spliced transcript variants encoding the same protein have been identified.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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