Thermo Fisher Scientific IL8 (CXCL8) Monoclonal Antibody (OTI14F10)

Thermo Fisher Scientific IL8 (CXCL8) Monoclonal Antibody (OTI14F10)

Applications

• Western Blot (WB)

Tested Dilution: 1:100

Product Specifications

Product Specific Information

• For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
• For conjugation experiments using this carrier-free antibody, perform an additional round of desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Interleukin 8 (IL-8, CXCL8) is a 72 amino acid pro-inflammatory factor belonging to the CXC subfamily of chemokines. It binds to cell surface receptors IL-8RA and IL-8RB and functions as a chemoattractant and potent angiogenic factor.
IL-8 expression and secretion are induced by various inflammatory stimuli in many cell types, including macrophages and endothelial cells. In endothelial cells, IL-8 is stored in Weibel-Palade bodies.
Originally isolated from osteosarcoma cells, IL-8 contains the ELR motif (N-terminal Glu-Leu-Arg sequence) and signals through CXCR1 and CXCR2 receptors.
Previous nomenclatures include neutrophil activating protein 1 (NAP-1), granulocyte chemotactic protein 1 (GCP-1), monocyte-derived neutrophil-activating peptide (MONAP), and protein 3-10C.
IL-8 and ten other members of the CXC chemokine gene family form a cluster mapped to chromosome 4q.
Cancer studies have demonstrated IL-8’s role in angiogenesis and tumor growth, and it is implicated in the pathogenesis of bronchiolitis caused by viral infection.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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