Thermo Fisher Scientific STEP Monoclonal Antibody (23E5)
STEP 단백질을 인식하는 마우스 단클론 항체(클론 23E5). Western blot, IHC, ICC 등 다양한 응용에 적합. Rat brain을 양성 대조군으로 권장. Human, Mouse, Rat 반응성. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-Dependent | - |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
| Immunoprecipitation (IP) | 1:50 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 23E5 |
| Immunogen | A synthetic peptide of STEP46 (amino acids 57–74: MCTPGCNEEGFGYLVSPR) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Ascites |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2173552 |
Product Specific Information
Suggested positive control: rat brain.
Target Information
Reversible phosphorylation of tyrosine residues is a key regulatory mechanism for numerous cellular events such as proliferation, differentiation, gene expression, and migration. Abnormalities in tyrosine phosphorylation contribute to various human diseases, including cancer and immune deficiencies.
There are at least 107 genes coding for protein tyrosine phosphatases (PTPs) in the human genome. All known PTPs share a conserved 12-amino-acid catalytic domain and are classified based on structural motifs.
Receptor-like PTPs have an extracellular domain, a single transmembrane region, and one or two intracellular phosphatase domains. Nonreceptor cytoplasmic PTPs contain a single phosphatase domain and additional motifs homologous to other protein classes.
PTPN5 (STEP), PTPRR, and PTPN7 form a family of phosphatases that specifically inactivate MAPKs (mitogen-activated protein kinases). Multiple STEP isoforms exist in the adult rat brain, showing regional enrichment related to cognitive, affective, and motor behaviors. Some isoforms arise from alternative splicing of a single STEP gene, each with distinct intracellular targets and functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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