Thermo Fisher Scientific S100A12 Monoclonal Antibody (OTI1D1), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:500

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:150

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

S100A12 is a member of the S100 family of calcium-binding proteins containing two EF-hand motifs. These proteins are found in the cytoplasm and/or nucleus and regulate various cellular processes such as cell cycle progression and differentiation.
S100A12 participates in calcium-dependent signal transduction and may affect cytoskeletal components to modulate neutrophil activities. It acts as a ligand for RAGE, triggering activation of mononuclear phagocytes, lymphocytes, and endothelial cells. This interaction activates NF-κB, a key transcription factor in inflammatory responses.
S100A12 also exhibits anti-microbial properties.

For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.