Thermo Fisher Scientific VE-cadherin Polyclonal Antibody
VE-cadherin 단백질을 인식하는 Rabbit Polyclonal 항체로, Human과 Mouse 시료에 반응합니다. Western blot과 ELISA에 사용 가능하며, 세포 간 결합 및 내피세포 연구에 적합합니다. 고순도 친화 크로마토그래피 정제 및 액상 형태로 제공됩니다.
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- PA587496
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:100–1:500 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 259–358 of human VE-Cadherin (NP_001786.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.01 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804200 |
Product Specific Information
Immunogen sequence:
TQTKYTFVVP EDTRVGTSVG SLFVEDPDEP QNRMTKYSIL RGDYQDAFTI ETNPAHNEGI IKPMKPLDYE YIQQYSFIVE ATDPTIDLRY MSPPAGNRAQ
Positive Samples:
U-87MG, A-549, SH-SY5Y, A-431, Mouse lung, Rat lung
Cellular Location:
Cell junction, Cell membrane, Single-pass type I membrane protein
Target Information
VE-cadherin is a calcium-dependent cell–cell adhesion glycoprotein and a member of the cadherin superfamily. It is located in a six-cadherin cluster on chromosome 16 and is associated with loss of heterozygosity events in breast and prostate cancer. The protein consists of five extracellular cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail. VE-cadherin plays an essential role in endothelial cell biology by regulating intercellular junction cohesion and organization. An alternative splice variant has been described, though the full-length sequence has not been fully determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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