Thermo Fisher Scientific JAK3 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
RLTTDSQHFF CKEVAPPRLL EEVAEQCHGP ITLDFAINKL KTGGSRPGSY VLRRSPQDFD SFLLTVCVQN PLGPDYKGCL IRRSPTGTFL LVGLSRPHSS LRELLATCWD GGLHVDGVAV TLTSCCIPRP KEKSNLIVVQ RGHSPPTSSL VQPQSQYQLS QMTFHKIPAD SLEWHENLGH G

Positive Samples: U-87MG
Cellular Location: Cytoplasm, Endomembrane system, Peripheral membrane protein

Target Information

Janus kinase 3 (JAK3) phosphorylates members of the STAT (signal transduction and activators of transcription) family. JAK3 is predominantly expressed in immune cells and transduces a signal in response to activation of interleukin receptors. In response to various cytokines or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at two adjacent tyrosine residues. The activation of JAKs can lead to the phosphorylation of STAT proteins, which dimerize and translocate to the nucleus. Once in the nucleus, STAT proteins modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. However, active JAK1 may be required for complex responses. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if correctly positioned within the IFN gamma-receptor complex.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.