Thermo Fisher Scientific Nogo Receptor Recombinant Rabbit Monoclonal Antibody (M5)

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

-

Flow Cytometry (Flow)

Assay-dependent

-

ELISA (ELISA)

Assay-dependent

-

Immunoprecipitation (IP)

Assay-dependent

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG, kappa

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

M5

Immunogen

(His)6-tagged fragment of rat NgR1 (amino acids 278-473). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Nogo Receptor,uniProtId:Q99M75-1,ncbiNodeId:10114,antigenRange:278-473,antigenLength:473,antigenImageFileName:MA5-47935_Nogo_Receptor_Q99M75-1_Rabbit.svg,antigenImageFileNamePDP:MA5-47935_Nogo_Receptor_Q99M75-1_Rabbit_PDP.jpeg,sortOrder:3}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS

Contains

0.02% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_3074379

Product Specific Information

Specificity: The antibody binds to human and rat NgR1 with a Kd of 2.9 nM for both species (bivalent binding).

Target Information

NOGO (RTN4R) is a receptor for RTN4, OMG, and MAG. Its signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. NOGO also mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult CNS. In addition, NOGO acts with RTN4 and LINGO1 to regulate neuronal precursor cell motility during cortical development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.