Thermo Fisher Scientific Paxillin Chimeric Recombinant Rabbit Monoclonal Antibody (LD4 sAB)
인간 Paxillin LD4 모티프(260-278)에 특이적으로 결합하는 재조합 토끼 단일클론 항체. Western blot 및 ELISA에 사용 가능. 높은 특이성과 친화도(Kd 6 nM)를 보유하며, Protein A로 정제된 액상 형태. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Assay-dependent
ELISA
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | LD4 sAB |
| Immunogen | Peptide corresponding to human paxillin-LD4 motif (residues 260–278) fused to MBP; peptide sequence: WGGSATRELDELMASLSD |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074386 |
Product Specific Information
- Specificity: The antibody binds specifically to the LD-4 motif of human paxillin with a Kd of 6 nM.
Target Information
Paxillin is a focal adhesion protein and a substrate for several tyrosine kinases such as src, FAK, and p210BRC/ABL. The tyrosine phosphorylation of paxillin is affected by conditions that change cell-cell adhesion. Paxillin associates tightly with FAK and Crk through its SH2 domain. This interaction is independent of the extracellular matrix. Although paxillin was initially discovered in fibroblasts, its phosphorylation may also be important during neurite extension during differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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