Thermo Fisher Scientific CD33 Chimeric Recombinant Rabbit Monoclonal Antibody (M195)
CD33 단백질을 인식하는 Thermo Fisher의 재조합 토끼 단클론 항체(M195). 인간 시료에 반응하며 ICC/IF, Flow Cytometry, Functional, RIA 등 다양한 연구 응용에 적합. 비결합형 액상 형태로 제공되며 Protein A로 정제됨. CD33 관련 백혈병 연구에 유용.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Immunocytochemistry (ICC/IF) | 10 µg/mL | |
| Flow Cytometry (Flow) | Assay-dependent | |
| Functional Assay (Functional) | Assay-dependent | |
| Radioimmune Assays (RIA) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | M195 |
| Immunogen | The original antibody was generated by immunizing mice with live leukemic myeloblasts. Target: CD33 (UniProt ID: P20138-1, Range: 1–364) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074789 |
Product Specific Information
This antibody binds CD33, a 67 kD glycoprotein expressed on monocytes, hematopoietic progenitors, early myeloid progenitor cells, and myeloid leukemias (acute and chronic). It is not expressed on mature myeloid cells, normal stem cells, other hematopoietic cells, or non-hematopoietic human tissues.
Target Information
CD33 is a transmembrane protein belonging to the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that recruit SHP-1 and SHP-2 phosphatases and participate in receptor regulation. CD33 is expressed on cells of the myelomonocytic lineage, binds sialic acid residues on cell surfaces, and serves as a therapeutic target for acute myeloid leukemia. It is found on granulocyte and macrophage precursors in bone marrow, but not on pluripotent stem cells. CD33 is also expressed on peripheral monocytes and is useful for distinguishing myelogenous leukemia cells from lymphoid or erythroid leukemias. Diseases associated with CD33 dysfunction include gallbladder lymphoma and extracutaneous mastocytoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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