Thermo Fisher Scientific Mesothelin Recombinant Mouse Monoclonal Antibody (IC14-30)

Applications

• ELISA (ELISA): Assay-dependent

Product Specifications

Product Specific Information

Specificity: This antibody binds the human mesothelin protein, which is highly expressed in many human cancers, including the majority of pancreatic adenocarcinomas, ovarian cancers, and mesotheliomas.

Target Information

Mesothelin was originally identified as a differentiation antigen of mesotheliomas, ovarian cystadenocarcinomas, and pancreatic adenocarcinomas. It is a glycosylphosphatidylinositol (GPI)-anchored, cell-surface glycoprotein predominantly secreted by mesothelial cells.
Although expressed at restricted levels in normal pleural, pericardial, and peritoneal mesothelial cells, aberrant expression has been reported in various cancers such as endometrioid uterine adenocarcinomas and squamous cell carcinomas of the esophagus, stomach, lung, and cervix.

Proteolytic cleavage of Mesothelin yields a soluble fragment known as megakaryocyte potentiating factor (MPF), which stimulates megakaryocyte colony-forming activity in murine bone marrow cultures. MPF and Mesothelin are suggested to play roles in tumorigenesis by promoting proliferation, migration, anchorage-independent growth, and tumor progression, contributing to heterotypic cell adhesion and metastasis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.