Thermo Fisher Scientific CD281 (TLR1) Monoclonal Antibody (eBioTR23 (TR23)), eFluor 660, eBioscience
마우스 TLR1(CD281)을 인식하는 eBioTR23 단클론 항체로, eFluor 660 형광 표지되어 있음. Flow Cytometry에 최적화되어 있으며, 1 µg/test로 사용 가능. 633 nm 레이저로 여기되어 668 nm에서 방출. 연구용으로만 사용.
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1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD281 (TLR1) Monoclonal Antibody (eBioTR23 (TR23)), eFluor 660, eBioscience
Thermo Fisher Scientific CD281 (TLR1) Monoclonal Antibody (eBioTR23 (TR23)), eFluor 660
Applications
- Flow Cytometry (Flow)
Tested Dilution: 1 µg/test
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), eFluor™ 660, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBioTR23 (TR23) |
| Conjugate | eFluor™ 660 |
| Excitation / Emission Max | 651 / 668 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2574305 |
Additional Formats
Product Specific Information
The eBioTR23 monoclonal antibody reacts with mouse Toll-like receptor 1 (TLR1, CD281), a ~98 kDa protein of the Toll-like receptor family, closely related to mouse TLR6 in both structure and function.
TLR1 forms a complex with TLR2 to bind bacterially derived triacyl lipopeptides and soluble factors from Neisseria meningitidis. It is expressed by macrophages; TLR1-deficient mice show impaired cytokine production upon stimulation with triacyl lipopeptides and mycobacterial lipoproteins.
Applications Reported: Flow cytometric analysis.
Applications Tested: Flow cytometric analysis of transfected cells at ≤1 µg/test (100 µL final volume; 10⁵–10⁸ cells/test).
Careful titration is recommended for optimal assay performance.
Fluorophore Information:
eFluor® 660 is a replacement for Alexa Fluor® 647.
- Excitation: 633–647 nm
- Emission: 668 nm
- Laser: Red laser
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
TLR1 protein is a member of the Toll-like receptor (TLR) family, fundamental in pathogen recognition and innate immunity activation.
TLRs recognize pathogen-associated molecular patterns (PAMPs) and mediate cytokine production essential for effective immunity.
They are conserved from Drosophila to humans, sharing structural and functional similarities.
In mice, TLR1 interacts with TLR2, enhancing NF-κB activation in response to synthetic lipopeptides.
TLR1 recognizes lipid configurations of mycobacterial lipoproteins and tri-acylated lipopeptides.
Alternative transcripts may result from polyadenylation site usage or splicing variations.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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