Thermo Fisher Scientific ZBED1 Monoclonal Antibody (OTI2H3), TrueMAB
ZBED1 단백질을 인식하는 Mouse monoclonal 항체로, Western blot과 Flow cytometry에 적합합니다. Human 시료에 반응하며, Lyophilized 형태로 제공됩니다. 고순도 친화 크로마토그래피 정제, PBS buffer(8% trehalose) 저장, -20°C 보관 권장.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2H3 |
| Immunogen | Full length human recombinant protein of human ZBED1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
ZBED1 (also known as DREF) is the human homolog of the Drosophila DREF protein, a transcriptional regulatory factor essential for the expression of genes involved in DNA replication and cell proliferation.
RNA interference experiments targeting ZBED1 RNA inhibited S-phase entry and reduced histone H1 mRNA levels in HeLa cells, suggesting a role in human cell proliferation.
At least 22 ribosomal proteins have ZBED1 binding sites in their promoters; anti-ZBED1 RNAi also decreased ribosomal protein gene expression.
Immunoprecipitation analyses indicate that ZBED1 self-associates in vivo via a carboxyl-terminal hATC domain, required for nuclear localization and DNA binding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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