Thermo Fisher Scientific ZBED1 Monoclonal Antibody (OTI2H3), TrueMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

ZBED1 (also known as DREF) is the human homolog of the Drosophila DREF protein, a transcriptional regulatory factor essential for the expression of genes involved in DNA replication and cell proliferation.
RNA interference experiments targeting ZBED1 RNA inhibited S-phase entry and reduced histone H1 mRNA levels in HeLa cells, suggesting a role in human cell proliferation.
At least 22 ribosomal proteins have ZBED1 binding sites in their promoters; anti-ZBED1 RNAi also decreased ribosomal protein gene expression.
Immunoprecipitation analyses indicate that ZBED1 self-associates in vivo via a carboxyl-terminal hATC domain, required for nuclear localization and DNA binding.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.