Thermo Fisher Scientific CD10 Monoclonal Antibody (eBioCB-CALLA (CB-CALLA)), Biotin, eBioscience

Applications and Tested Dilution

Product Specifications

Available Conjugate Formats

• Unconjugated
• Alexa Fluor 700
• APC
• APC-eFluor 780
• FITC
• NovaFluor Blue 610-70S
• NovaFluor Blue 660-120S
• NovaFluor Red 700
• NovaFluor Yellow 610
• NovaFluor Yellow 660
• PE
• PE-Cyanine5
• PE-Cyanine7
• PerCP-eFluor 710
• Super Bright 436 / 600 / 645 / 702 / 780
• Request custom conjugation

Product Specific Information

The eBioCB-CALLA monoclonal antibody recognizes human CD10 (CALLA, NEP, Neprilysin), a 100 kDa type II cell surface glycoprotein originally identified in acute lymphoblastic leukemia (ALL). CD10 is a Zn²⁺-dependent metallopeptidase involved in regulating chemotactic and inflammatory processes, and in B cells, it modulates stromal cell–dependent lymphopoiesis. It is expressed in enterocytes, renal tubules, and glomeruli.

Applications Reported: Flow cytometric analysis.
Applications Tested: Flow cytometric analysis of normal human peripheral blood cells at ≤ 0.5 µg/test (100 µL final volume). Cell number range: 10⁵–10⁸ cells/test. Optimal titration recommended.
Filtration: 0.2 µm post-manufacturing filtered.

Target Information

CD10 (Common Acute Lymphocytic Leukemia Antigen, CALLA) is a cell surface enzyme with neutral metalloendopeptidase activity that inactivates biologically active peptides. Expressed in lymphoblastic, Burkitt’s, and germinal center lymphomas, immature B cells, and various epithelial tissues (kidney, gut, breast). CD10 cleaves peptides at hydrophobic residues, inactivating hormones such as glucagon, enkephalins, and bradykinin. It is a 100 kDa type II transmembrane glycoprotein encoded by a > 45 kb gene with alternatively spliced 5′ UTRs.

Diseases associated with CD10 dysfunction include spinocerebellar ataxia 43 and Charcot–Marie–Tooth disease.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.