Thermo Fisher Scientific CD9 Monoclonal Antibody (eBioSN4 (SN4 C3-3A2)), Biotin, eBioscience
인간 CD9 단백질을 인식하는 Biotin 결합 마우스 단클론 항체로, 유세포 분석에 최적화됨. 0.5 µg/test 농도로 사용 가능하며, 암세포 이동 억제 및 면역세포 활성 연구에 활용. 4°C 암소 보관, 동결 금지.
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Thermo Fisher Scientific CD9 Monoclonal Antibody (eBioSN4 (SN4 C3-3A2)), Biotin, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | View 1 publication |
| Flow Cytometry (Flow) | 0.5 µg/test | View 8 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Biotin, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBioSN4 (SN4 C3-3A2) |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_657779 |
| Filtration | 0.2 µm post-manufacturing filtered |
Available Formats
- Unconjugated
- APC
- FITC
- PE
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 645
- Request custom conjugation
Product Specific Information
Description:
The eBioSN4 monoclonal antibody reacts with human CD9, a 24 kDa member of the tetraspanin family characterized by four hydrophobic transmembrane domains. CD9 is expressed in platelets, eosinophils, basophils, pre-B cells, activated T cells, and neural cell lines.
CD9 expression is associated with malignant phenotypes, including non-T cell acute lymphoblastic leukemia and chronic lymphocytic leukemia. In platelets, CD9 interacts with integrin αIIb/βIII to mediate platelet aggregation. It also induces aggregation and migration in pre-B and Schwann cells and provides co-stimulatory signals for T cells independently of CD28.
Binding of eBioSN4 partially cross-blocks another anti-human CD9 antibody, MM2/57.
Applications Reported: Flow cytometric analysis
Applications Tested: Tested by flow cytometry; optimal performance at ≤ 0.5 µg/test (100 µL final volume, 10⁵–10⁸ cells/test).
Careful titration recommended.
Target Information
CD9 antigen is a glycoprotein expressed on developing B lymphocytes, platelets, monocytes, eosinophils, basophils, stimulated T lymphocytes, neurons, and glial cells. It belongs to the tetraspanin family with four transmembrane domains.
In pre-B cells and platelets, CD9 regulates activation and aggregation via integrin CD41/CD61. It plays roles in cell motility, osteoclastogenesis, neurite outgrowth, myotube formation, sperm-egg fusion, and T cell stimulation.
CD9 contributes to differentiation, adhesion, and signal transduction and acts as a metastasis suppressor in solid tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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