Thermo Fisher Scientific RWDD3 Monoclonal Antibody (OTI10H4), TrueMAB
인간 RWDD3 단백질을 표적으로 하는 Mouse IgG2a 단일클론 항체. Western blot에 적합하며, 무보존제 동결건조 형태로 제공. SUMO 결합 조절 및 염증 신호 연구에 활용 가능. 연구용으로만 사용.
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- CF811763
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Thermo Fisher Scientific RWDD3 Monoclonal Antibody (OTI10H4), TrueMAB
Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI10H4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–267 of human RWDD3 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to reach a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
RWDD3 (RSUME) is a small RWD-containing protein that enhances SUMO conjugation within immune-inflammatory signaling pathways. RWDD3 increases Ikappa-Beta sumoylation and stability, inhibiting TNF-α-induced kappaB-LUC reporter activity.
RSUME-mediated sumoylation of Ikappa-Beta suppresses NF-kappa-Beta activity on inflammatory genes such as IL-8 and COX-2, contributing to anti-inflammatory responses.
RWDD3 expression is induced under hypoxic conditions and may play a role in vascularization. BMP-4 and RWDD3 are potential targets for inhibiting pituitary tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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