Thermo Fisher Scientific SH3PXD2A Monoclonal Antibody (OTI4B8), TrueMAB
SH3PXD2A 단백질을 인식하는 마우스 모노클로날 항체로, Western blot에 적합합니다. Human, Mouse, Rat 반응성이 있으며, Lyophilized 형태로 제공됩니다. PBS 버퍼에 8% 트레할로스 포함, -20°C 보관 권장.
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Applications
- Western Blot (WB): 1:2,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4B8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 299–395 of human SH3PXD2A produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
SH3PXD2A is an adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation, and cancer cell invasiveness.
It binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs), and phosphoinositides, acting as an organizer for NOX1/NOX3-dependent ROS generation and localization.
In association with ADAM12, it mediates the neurotoxic effect of amyloid-beta peptide.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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