Thermo Fisher Scientific WHSC2 Monoclonal Antibody (6B11H8)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:1,000

-

Immunocytochemistry (ICC/IF)

1:200-1:1,000

-

Flow Cytometry (Flow)

1:200-1:400

-

ELISA (ELISA)

1:10,000

-

Product Specifications

Species Reactivity

Human, Rat

Published species

Human

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

6B11H8

Immunogen

Purified recombinant fragment of human WHSC2 (amino acids: 280-511) expressed in E. Coli. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:WHSC2,uniProtId:Q9H3P2-1,ncbiNodeId:9606,antigenRange:280-511,antigenLength:528,antigenImageFileName:MA5-17199_WHSC2_Q9H3P2-1_House_mouse.svg,antigenImageFileNamePDP:MA5-17199_WHSC2_Q9H3P2-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2538670

Product Specific Information

MA5-17199 targets WHSC2 in indirect ELISA, FACS, ICC, IHC, IF and WB applications and shows reactivity with Human and Rat samples.

The MA5-17199 immunogen is purified recombinant fragment of human WHSC2 (amino acids: 280-511) expressed in E. Coli.

MA5-17199 detects WHSC2 which has a predicted molecular weight of approximately 57.3kDa.

Target Information

This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.