Thermo Fisher Scientific VAV1 Monoclonal Antibody (2E11)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:250

View 1 publication 1 publication

Flow Cytometry (Flow)

1:200-1:400

-

ELISA (ELISA)

1:10,000

-

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

2E11

Immunogen

Purified recombinant fragment of human VAV1 (amino acids: 121-324) expressed in E. Coli. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:VAV1,uniProtId:P15498-1,ncbiNodeId:9606,antigenRange:121-324,antigenLength:845,antigenImageFileName:MA5-17198_VAV1_P15498-1_House_mouse.svg,antigenImageFileNamePDP:MA5-17198_VAV1_P15498-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2538669

Product Specific Information

MA5-17198 targets VAV1 in FACS, indirect ELISA, and WB applications and shows reactivity with Human samples.

The MA5-17198 immunogen is purified recombinant fragment of human VAV1 (amino acids: 121-324) expressed in E. Coli.

MA5-17198 detects VAV1 which has a predicted molecular weight of approximately 98.3kDa.

Target Information

This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.