Thermo Fisher Scientific VAV1 Monoclonal Antibody (2E11)
인간 VAV1 단백질을 표적으로 하는 Mouse IgG1 단클론 항체로, WB, Flow Cytometry, ELISA에 적합합니다. 정제된 재조합 VAV1(aa 121-324)을 면역원으로 사용했으며, 단백질 G로 정제된 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific VAV1 Monoclonal Antibody (2E11)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:250 | View 1 publication |
| Flow Cytometry (Flow) | 1:200–1:400 | - |
| ELISA | 1:10,000 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2E11 |
| Immunogen | Purified recombinant fragment of human VAV1 (amino acids 121–324) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C for short term. For long term, store at −20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538669 |
Product Specific Information
MA5-17198 targets VAV1 in FACS, indirect ELISA, and WB applications, showing reactivity with human samples.
The immunogen is a purified recombinant fragment of human VAV1 (amino acids 121–324) expressed in E. coli.
This antibody detects VAV1, which has a predicted molecular weight of approximately 98.3 kDa.
Target Information
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. It interacts with adenovirus E3-14.7K protein and may utilize TNF-α or Fas-ligand pathways to mediate apoptosis, inflammation, or vasoconstriction. Optineurin may also function in cellular morphogenesis, membrane trafficking, vesicle trafficking, and transcription activation through interactions with RAB8, huntingtin, and transcription factor IIIA proteins.
Alternative splicing results in multiple transcript variants encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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