Thermo Fisher Scientific LL-37 Polyclonal Antibody
LL-37 인간 단백질을 인식하는 Sheep Polyclonal 항체로 WB, IHC, ICC/IF에 사용 가능. 동결건조 형태로 제공되며 PBS 버퍼에 보존. 감염 방어 및 면역 반응 연구에 적합. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | – |
| Immunohistochemistry (IHC) | 10–50 µg/mL | – |
| Immunocytochemistry (ICC/IF) | 50 µg/mL | – |
| Miscellaneous (PubMed) | – | View 1 publication |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from human Cathelicidin antimicrobial peptide conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: Cathelicidin antimicrobial peptide (LL-37).
Target Information
Cathelicidin is an epithelial-derived antimicrobial protein found in specific granules of polymorphonuclear leukocytes of bone marrow, testis, and neutrophils.
These peptides are characterized by conserved pro-peptide sequences and are expressed in epithelial tissues and some myeloid cells of humans and animals.
LL-37/hCAP-18 is the only Cathelicidin found in humans, expressed in inflammatory and epithelial cells, and plays a crucial role in defense against bacterial infection in skin.
Beyond antimicrobial activity, Cathelicidins mediate innate and adaptive immunity, including endotoxin neutralization, angiogenesis, wound healing, and promoting neutrophil chemotaxis and mast cell recruitment.
Cathelicidin antimicrobial peptides are considered potential prototypes for innovative drugs targeting infection and immune modulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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