Thermo Fisher Scientific MPR 300 Polyclonal Antibody
MPR 300 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 IHC(P)에서 사용 가능. 사람, 마우스, 랫트 반응성. 동결건조 형태로 제공되며, 4°C 또는 -20°C에서 보관. 연구용으로만 사용 가능.
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- OSI00001W-100UL
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from human MPR 300 conjugated to blue carrier protein was used as the antigen |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide is homologous in rat and mouse.
- Specificity of this antibody: MPRI.
Target Information
Lysosomal enzymes containing one or two mannose 6-phosphate (man6P) moieties are transported in the cell by approximately 300 kDa cation-independent mannose 6-phosphate receptors (CI-MPR).
The biosynthetic cycle involves MPR transport of newly synthesized lysosomal enzymes from the trans-Golgi network to late endosomes or early lysosomes.
The endocytic cycle moves extracellular lysosomal enzymes from the plasma membrane to early endosomes via clathrin-coated vesicles.
MPRs cycle between these compartments every 3 hours, with steady-state distribution mainly in late endosomes, fewer in the trans-Golgi network, and about 10% at the cell surface.
MPR also binds type II insulin-like growth factor (IGF-II) and can bind both man6P and IGF-II simultaneously.
A soluble ~240 kDa truncated form of MPR, representing the extracellular domain, circulates in serum and retains ligand-binding capability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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